Steroids Blog

Dianabol (methandrostenolone)

2007-10-17T00:28:00.000-07:00

Dianabol (methandrostenolone)

Quick overview:

Active Life: 6-8 hours
Drug Class: Anabolic/Androgenic Steroid (Oral)
Average Dose: Men 15-50 mg/day......Women 5-10 mg/day
Acne: Yes, especially in higher dosages
Water Retention: Yes, similar to testosterone
High Blood Pressure: Yes
Liver Toxic: Yes
Aromatization: Yes
DHT Conversion: No
Decrease HPTA function: Yes, dose and cycle length dependant

Dianabol is the old Ciba brand name for the oral steroid methandrostenolone. It is a derivative of testosterone, exhibiting strong anabolic and moderate androgenic properties. This compound was first made available in 1960, and it quickly became the most favored and widely used anabolic steroid in all forms of athletics. This is likely due to the fact that it is both easy to use and extremely effective. In the U.S. Dianabol production had meteoric history, exploding for quite some time, then quickly dropping out of sight. Many were nervous in the late 80's when the last of the U.S. generics were removed from pharmacy shelves, the medical community finding no legitimate use for the drug anymore. But the fact that Dianabol has been off the U.S. market for over 10 years now has not cut its popularity. It remains the most commonly used black market oral steroid in the U.S. As long as there are countries manufacturing this steroid, it will probably remain so.

Similar to testosterone and Anadrol 50, Dianabol is a potent steroid, but also one which brings about noticeable side effects. For starters methandrostenolone is quite estrogenic. Gynecomastia is often a concern during treatment, and may present itself quite early into a cycle (particularly when higher doses are used). At the same time water retention can become a pronounced problem, causing a notable loss of muscle definition as both subcutaneous water and fat build. Sensitive individuals may therefore want to keep the estrogen under control with the addition of an anti-estrogen such as Nolvadex and/or Proviron. The stronger drugs Arimidex, Femara, or Aromasin (antiaromatase) would be a better choice if available.

In addition, androgenic side effects are common with this substance, and may include bouts of oily skin, acne and body/facial hair growth. Aggression may also be increased with a potent steroid such as this, so it would be wise not to let your disposition change for the worse during a cycle. With Dianabol there is also the possibility of aggravating a male pattern baldness condition. Sensitive individuals may therefore wish to avoid this drug and opt for a milder anabolic such as Deca-Durabolin. While Dianabol does convert to a more potent steroid via interaction with the 5-alpha reductase anzyme (the same enzyme responsible for converting testosterone to dihydrotestosterone), it has extremely little affinity to do so in the human body's. The androgenic metabolite 5alpha dihydromethandrostenolone is therefore produced only in trace amounts at best. Therefore the use of Proscar/Propecia would serve no real purpose.

Being moderately androgenic, Dianabol is really only a popular steroid with men. When used by women, strong virilization symptoms are of course a possible result. Some do however experiment with it, and find low doses (5mg) of this steroid extremely powerful for new muscle growth. Whenever taken, Dianabol will produce exceptional mass and strength gains. It's effectiveness is often compared to other strong steroids like testosterone and Anadrol 50, and it is likewise a popular choice for bulking purposes. A daily dosage of 20-40mg is enough to give almost anybody dramatic results. Some do venture much higher in dosage, but this practice usually leads to a more profound incidence of side effects. It additionally combines well with a number of other steroids. It is noted to mix particularly well with the mild anabolic Deca-Durabolin. Together one can expect an exceptional muscle and strength gains, with side effects not much worse than one would expect from Dianabol alone. For all out mass, a long acting testosterone ester like enanthate can be used. With the similarly high estrogenic/androgenic properties of this androgen, side effects may be extreme with such a combination however. Gains would be great as well, which usually makes such an endeavor worthwhile to the user. As discussed earlier, ancillary drugs can be added to reduce the side effects associated with this kind of cycle.

In order to withstand oral administration, this compound is c17 alpha alkylated. We know that this alteration protects the drug from being deactivation by the liver (allowing nearly all of the drug entry into the bloodstream), however it can also be toxic to this organ. Prolonged exposure to c17 alpha alkylated substances can result in actual damage, possibly even the development of certain kinds of cancer. To be safe one might want to visit the doctor a couple of times during each cycle to keep an eye on their liver enzyme values. Cycles should also be kept short, usually less than 8 weeks long to avoid doing any noticeable damage. Jaundice (bile duct obstruction) is usually the first visible sign of liver trouble, and should be looked out for. This condition produces an unusual yellowing of the skin, as the body has trouble processing bilirubin. In addition to the skin, the whites of the eyes may also yellow, a clear indicator of trouble. Should this occur the drug should be discontinued immediately and a doctor visited. This is usually a point where further, permanent damage can be avoided.

It is also interesting to note that methandrostenolone is structurally identical to boldenone (EQ), except that it contains the added c17 alpha alkyl group discussed above. This fact makes clear the impact of altering a steroid in such a way, as these two compounds appear to act very differently in the body. The main dissimilarity seems to lie in the tendency for estrogenic side effects, which seems to be much more pronounced with Dianabol. Equipoise is known to be quite mild in this way, and users therefore commonly take this drug without any need of an anti-estrogen. Dianabol is much more estrogenic not because it is more easily aromatized, as in fact the 17 alpha methyl group and c1-2 double bond both slow the process of aromatization. The problem is that methandrostenolone converts to l7alpha methylestradiol, a more biologically active form of estrogen than regular estradiol. But Dianabol also appears to be much more potent in terms of muscle mass compared to boldenone, supporting the notion that estrogen does play an important role in anabolism. In fact boldenone and methandrostenolone differ so much in their potencies as anabolics that the two are rarely though of as related. As a result, the use of Dianabol is typically restricted to bulking phases of training while Equipoise is considered an excellent cutting or lean-mass building steroid.

The half-life of Dianabol is only about 3 to 4 hours, a relatively short time. This means that a single daily dosage schedule will produce a varying blood level, with ups and downs throughout the day. The user likewise has a choice, to either split up the tablets during the day or to take them all at one time. The usual recommendation has been to divide them and try to regulate the concentration in your blood. This however, will produce a lower peak blood level than if the tablets were taken all at once, so there may be a trade off with this option. The steroid researcher Bill Roberts also points out that a single-episode dosing schedule should have a less dramatic impact on the hypothalamic-pituitary-testicular axis, as there is a sufficient period each day where steroid hormone levels are not extremely exaggerated. I tend to doubt hormonal stability can be maintained during such a cycle however, but do notice that anecdotal evidence often still supports single daily doses to be better for overall results. Perhaps this is the better option. Since we know the blood concentration will peak about 1.5 to 3 hours after administration, we may further wonder the best time to take our tablets. It seems logical that taking the pills earlier in the day, preferably some time before training, would be optimal. This would allow a considerable number of daytime hours for an androgen rich metabolism to heighten the uptake of nutrients, especially the critical hours following training.

Oxandrolone (Oxandrin) - ANAVAR

2007-10-15T02:39:00.000-07:00

Oxandrolone (Oxandrin) is an anabolic steroid created by Searle Laboratories under the trademark Anavar, and introduced into the US in 1964. It is taken orally, and unlike other steroids delivered in this manner, most of which are Class II steroids, the majority of its effects are due to reaction with the androgen receptor. In sufficient dosage, Oxandrolone is highly likely to bind well with the receptor, and is therefore a Class I steroid, while having few other side-effects. The drug was prescribed for a number of medical disorders causing involuntary weight loss, in order to promote muscle regrowth. It had also been shown to be partially successful in treating cases of osteoporosis. However, in part due to bad publicity from its illegal use by bodybuilders, Oxandrolone was discontinued by Searle Laboratories in 1989. It was picked up by Bio-Technology General Corporation who, following successful clinical trials in 1995, released it under the tradename Oxandrin. It was approved for orphan drug status by the Food and Drug Administration (FDA) in treating alcoholic hepatitis, Turner's syndrome, and weight loss caused by HIV. In addition, the drug has shown positive results in treating anaemia and hereditary angioedema. Clinical studies however have shown links between prolonged use of the drug and problems of liver toxicity similar to those found with other 17α-alkylated steroids. Even in small dosages, many users reported gastro-intestinal problems such as bloating, nausea, and diarrhoea. Before the Controlled Substances Act was passed to restrict the production, sale, and usage of anabolic steroids, Oxandrolone's characteristics lent itself well towards use by female athletes. Its specificity targeting the androgen receptor meant that, unlike many other steroids, it had not been reported to cause stunted growth in younger users, and at typical dosage rarely caused noticeable masculinising effects outside of stimulating muscle growth. In addition, Oxandrolone does not aromatise at any dosage, and is not easily metabolised into DHT or oestrogen. As such, a typical dose of 20-30 mg provided elevated androgen levels for up to eight hours. To increase effectiveness, bodybuilders typically "stacked" the drug with others such as Testosterone, further enhancing body mass gain.

Testosterone cypionate

2007-10-10T22:32:00.001-07:00

Testosterone cypionate

Quick overview:

Active Life: 15-16 days
Drug Class: Anabolic/Androgenic Steroid (for injection)
Average Dose: Men 250-1000 mg/week
Acne: Yes
Water Retention: Yes, high
High Blood Pressure: Yes
Liver Toxic: Low, except in mega dosages
Aromatization:Yes, high
DHT Conversion: Yes, high
Decrease HPTA function: Yes, severe

American athletes have a long and fond relationship with Testosterone cypionate. While Testosterone enanthate is manufactured widely throughout the world, cypionate seems to be almost exclusively an American item. It is therefore not surprising that American athletes particularly favor this testosterone ester. But many claim this is not just a matter of simple pride, often swearing cypionate to be a superior product, providing a bit more of a "kick" than enanthate. At the same time it is said to produce a slightly higher level of water retention, but not enough for it to be easily discerned. Of course when we look at the situation objectively, we see these two steroids are really interchangeable, and cypionate is not at all superior. Both are long acting oil-based injectables, which will keep testosterone levels sufficiently elevated for approximately two weeks. Enanthate may be slightly better in terms of testosterone release, as this ester is one carbon atom lighter than cypionate (remember the ester is calculated in the steroids total milligram weight). The difference is so insignificant however that no one can rightly claim it to be noticeable (we are maybe talking a few milligrams per shot). Regardless, cypionate came to be the most popular testosterone ester on the U.S. black market for a very long time

As with all testosterone injectables, one can expect a considerable gain in muscle mass and strength during a cycle. Since testosterone readliy converts to estrogen, the mass gained from this drug is likely to be accompanied by quite a bit of water retention. The resulting loss of definition of course makes cypionate a very poor choice for dieting or cutting phases. The excess level of estrogen brought about by this drug can also cause one to develop gynecomastia rather quickly. Should one notice an uncomfortable soreness, swelling or lump under the nipple, an ancillary drug like Nolvadex should be added immediately. This will minimize the effect of estrogen greatly, making the steroid much more tolerable to use. The powerful anti-aromatases Arimidex, Femara, or Aromasin are yet a better choice. Those who have a known sensitivity to estrogen may find it more beneficial to use ancillary drugs like Nolvadex and Proviron from the onset of the cycle, in order to prevent estrogen related side effects before they become apparent.

Since testosterone is the primary male androgen, we should also expect to see pronounced androgenic side effects with this drug. Much intensity is related to the rate in which the body converts testosterone into dihydrotestosterone (DHT). This, as you know, is the devious metabolite responsible for the high prominence of androgenic side effects associated with testosterone use. This includes the development of oily skin, acne, body/facial hair growth and male pattern balding. Those worried that they may have a genetic predisposition toward male pattern baldness may wish to avoid testosterone altogether. Others opt to add the ancillary drug Proscar/Propecia, that prevents the conversion of testosterone to dihydrotestosterone. This can greatly reduce the chance for running into a hair loss problem, and will probably lower the intensity of other androgenic side effects. Although active in the body for much longer time, cypionate is injected on a weekly or bi-weekly basis in order to maintain stable blood levels. At a dosage of 250mg to 800mg per week we should certainly see dramatic results. It is interesting to note that while a large number of other steroidal compounds have been made available since testosterone injectables, they are still considered to be the dominant bulking agents among bodybuilders. There is little argument that these are among the most powerful mass drugs. When taking dosages above 800-1000mg per week there is little doubt that water retention will come to be the primary gain, far outweighing the new mass accumulation. The practice of "megadosing" is therefore inefficient, especially when we take into account the typical high cost of steroids today.

It is also important to remember that the use of an injectable testosterone will quickly suppress endogenous testosterone production. It is therefore mandatory to complete a proper post cycle therapy, constisting of HCG and Clomid or Nolvadex at the conclusion of a cycle. This should help the user avoid a strong "crash" due to hormonal imbalance, which can strip away much of the new muscle mass and strength. This is no doubt the reason why many athletes claim to be very disappointed with the final result of steroid use, as there is often only a slight permanent gain if anabolics are discontinued incorrectly. Of course we cannot expect to retain every pound of new bodyweight after a cycle. This is especially true whenever we are withdrawing a strong (aromatizing) androgen like testosterone, as a considerable drop in weight (and strength) is to be expected as retained water is excreted. This should not be of much concern; instead the user should focus on ancillary drug therapy so as to preserve the solid mass underneath. Another way athletes have found to lessen the "crash", is to first replace the testosterone with a milder anabolic like Deca-Durabolin. This steroid is administered alone, at a typical dosage (200-400mg per week), for the following month or two. In this "stepping down" procedure the user is attempting to turn the watery bulk of a strong testosterone into the more solid muscularity we see with nandrolone preparations. In many instances this practice proves to be very effective. Of course we must remember to still administer ancillary drugs at the conclusion, as endogenous testosterone production will not be rebounding during the Deca therapy.

Testosterone cypionate

2007-10-09T03:51:00.001-07:00

Testosterone cypionate

2007-10-06T02:23:00.000-07:00

THG Steroids by Balco

2007-10-04T04:36:00.001-07:00

THG Steroids by Balco

Known as a “designer” steroid, THG’s complete name is tetrahydrogestrinone, and is used by athletes to enhance their performance.
The United States Food and Drug Administration issued a statement on October 28, 2003 that THG is a new unapproved drug.
It therefore cannot be marketed without the FDA’s approval because it poses some health risks to consumers, and (not surprisingly) is working with other agencies to aggressively enforce this prohibition. While manufacturers would most likely introduce THG as a dietary supplement, the FDA believes that it does not meet the official definition of what a dietary supplement is.
THG, according to the FDA, is associated with two other synthetic anabolic steroids: gestrinone and trenbolone and they are taken by athletes who want to build muscle mass. THG was reported to the FDA by the US Anti-Doping Agency.

THG Steroid News
In 2003, four US Track and Field athletes and at least one famous European sprinter were discovered to have used THG. A scandal erupted involving the use of THG; and suggests that it was manipulated by chemists so that it becomes undetectable during doping tests. The scandal apparently began when an athletics coach anonymously contacted the US Anti-Doping Agency reporting that top athletes have been using THG. He then submitted a syringe containing THG to the doping agency, and they proceeded to analyze the components.
The reason athletes use THG is to deliver a top notch performance during competition and to have a boost of strength during competition. THG is also used to enable tired athletes recover quickly from the rigorous training. If the name “Balco” ever comes up in steroid conversation, it was identified by the FDA as the source of THG.

THG: Friend or Foe?
Opinion is divided about the use of enhancers by athletes. Professional sports can be a taxing occupation, and fatigue is the number one enemy of athletic competition. There are therefore groups of individuals who would support the use of THG while others espouse zero tolerance for any type of drug or supplement in professional competition.
Even if the use of steroids is pervasive in sports today, efforts continue to prevent athletes from using it. As a result of the scandal, the World Anti-Doping Agency (WADA) has transmitted testing methods for THG to all laboratories involved with the International Olympic Committee.
The test for THG detection was developed by the University of California in Los Angeles, and is now officially going to be used as part of the regular blood doping screening process conducted by laboratories.

THG Steroid Dangers
THG, like other anabolic steroids, is potentially very dangerous. It can cause damage to the liver, cause heart disease and trigger rage and anxiety. Although not enough scientific evidence can prove it, doctors believe that THG, because of its components, can also cause hair growth in women, and baldness and infertility in men.
Since the scandal broke out, more sports will be employing THG testing. These include horseracing (where urine samples of thoroughbreds will be tested for THG), the International Ski Federation, the NCAA, and others.

Oxandrolone (Oxandrin) - ANAVAR

2007-10-03T05:40:00.000-07:00

Anabolic and virilizing effects

2007-10-02T02:56:00.001-07:00

Anabolic androgenic steroids produce both anabolic and virilization (also known as androgenic) effects. Most anabolic steroids work in two simultaneous ways. First, they work by binding the androgen receptor and increasing protein synthesis. Second, they also reduce recovery time by blocking the effects of the stress hormone, cortisol, on muscle tissue. As a result, catabolism of the body's muscle mass is greatly reduced. Examples of anabolic effects: Increased protein synthesis from amino acids Increased muscle mass and strength[4][5][6] Increased appetite Increased bone remodeling and growth Stimulation of bone marrow increasing production of red blood cells Examples of virilizing/androgenic effects: Growth of the clitoris (clitoral hypertrophy) in females and the penis in male children (the adult penis does not grow indefinitely even when exposed to high doses of androgens) Increased growth of androgen-sensitive hair (pubic, beard, chest, and limb hair) Increased vocal cord size, deepening the voice Increased libido Suppression of endogenous sex hormones Impaired spermatogenesis

Deca-Durabolin ( Nandrolone )

2007-09-29T04:36:00.000-07:00

Nandrolone is an anabolic steroid occurring naturally in the human body, albeit in small quantities. Nandrolone is most commonly sold commercially as its decanoate ester (Deca-Durabolin) and less commonly as a phenylpropionate ester (Durabolin). Nandrolone use is indirectly detectable in urine tests by testing for the presence of 19-norandrosterone, a metabolite of this molecule. The International Olympic Committee has set a limit of 2 ng per ml of urine as the upper limit, beyond which an athlete is suspected of doping. Contents [hide]1 Detection Methods 2 Metabolism 3 Controversial abuse cases 4 External Links Detection MethodsUrine analysis as a method of detecting nandrolone abuse has recently become somewhat controversial, following studies by the University of Aberdeen showing that the metabolite product can also show up in urine in quantities above the upper limit from a combination of high-protein diets utilising the legal nutritional supplement creatine and hard cardiovascular exercise. The reason for this unexpected result has not been determined. Another possible (though unlikely) reason for a false positive result is the consumption of beef from cattle treated with steroids including nandrolone (used in overturning the verdict against the bobsleigh racer, Lenny Paul). Heavy consumption of the essential amino acid lysine (as indicated in the treatment of cold sores) has also shown false positives in some and was cited by American Shotputter C.J. Hunter as the reason for his positive test. A final possible cause of incorrect urine test results is the presence of metabolites from other anabolic steroids. However, as all such substances are also banned, this source is somewhat insignificant when interpreting the results of such a test. As a result of the numerous overturned verdicts, the testing procedure was reviewed by UK Sport [1] in 2000. Metabolism Nandrolone binds to the androgen receptor to a greater degree than testosterone, but due to its inability to act on the muscle in ways unmediated by the receptor, has less overall effect on muscle growth. The drug is also unusual in that unlike most anabolic steroids, it is not broken down into the more reactive DHT by the enzyme 5α-reductase, but rather into a less effective product. As such, some of the negative effects associated with most such drugs are somewhat mitigated. The positive effects of the drug include muscle growth, appetite stimulation and increased red blood cell production and bone density. Clinical studies have shown it to be effective in treating anaemia, osteoporosis and some forms of neoplasia including breast cancer, and also acts as a progestin-based contraceptive. For these reasons, nandrolone received FDA approval in 1983, and while sale is now restricted by the Controlled Substances Act, it remains available by prescription in most countries. In addition to legal production, Nandrolone is also extensively produced and used by athletes and bodybuilders seeking an edge in professional competition. Because nandrolone is not broken down into DHT, the deleterious effects common to most anabolic steroids on the scalp, skin, and prostate are lessened to a degree. The lack of alkylation on the 17α-carbon drastically reduces the drug's liver toxicity. Estrogenic effects resulting from reaction with aromatase are also mitigated as a result of the drug being a progestin, but effects such as gynaecomastia and reduced libido still occur in larger doses. Other side-effects can include erectile dysfunction and cardiovascular damage, as well as several ailments resulting from the drug's effect of lowering levels of luteinizing hormone through negative feedback. Controversial abuse cases QV Nandrolone Deca, a form of nandrolone used by atheletes Shoaib Akhtar, Pakistani cricketer (Did not contest presence of nandrolone in sample but was cleared of intentionally taking nandrolone by the Pakistan Cricket Board. WADA guidelines state that ignorance of substances an athlete has in his body is not a valid defence unless the athlete can clearly prove "no fault or negligence". Despite Akhtar neither demonstrating such nor providing any of the supposedly contaminated supplements which were to blame, the PCB overturned the two-year ban imposed. WADA is currently appealing the case to the Court of Arbitration for Sport.) Mohammad Asif, Pakistani cricketer (Did not contest presence of nandrolone in sample but was cleared of intentionally taking nandrolone by the Pakistan Cricket Board. WADA guidelines state that ignorance of substances an athlete has in his body is not a valid defence unless the athlete can clearly prove "no fault or negligence". Despite Asif neither demonstrating such nor providing any of the supposedly contaminated supplements which were to blame and admitting that he had received multiple injections which he did not know the contents of, the PCB overturned the one-year ban imposed. WADA is currently appealing the case to the Court of Arbitration for Sport.) Dieter Baumann, German long-distance runner Bryan Berard, American ice hockey player Linford Christie, British sprinter Edgar Davids, Dutch football player Christophe Dugarry, French football player Jason Giambi, American baseball player Latasha Jenkins, American sprinter Sesil Karatantcheva, Bulgarian tennis player Petr Korda, Czech tennis player Shawne Merriman, San Diego Chargers Linebacker Halil Mutlu, Turkish weight lifter Merlene Ottey, Jamaican 200m sprint World Champion Nuno Assis, (Portugal) SL Benfica Midfielder Lenny Paul, British bobsleigh racer Mark Richardson, British sprinter Orlando Salido, Mexican boxer James Toney, American boxer Craig Trindall, Australian rugby league player Dougie Walker, British sprinter

Stanozolol - winstrol

2007-09-28T02:29:00.000-07:00

Stanozolol - winstrol Stanozolol, commonly sold under the name Winstrol (oral) and Winstrol Depot (intra-muscular), was developed by Winthrop Laboratories in 1962. It is a synthetic anabolic steroid derived from testosterone, and has been approved by the FDA for human use. Unlike most injectable anabolic steroids, Stanozolol is not esterified and is sold as an aqueous suspension, or in oral tablet form. The drug has a large oral bioavailability, due to a C17 α-alkylation which allows the hormone to survive first pass liver metabolism when ingested. It is because of this that Stanozolol is also sold in tablet form. Stanozolol has been used on both animal and human patients for a number of conditions. In humans, it has been demonstrated to be successful in treating anaemia and hereditary angioedema. Veterinarians may prescribe the drug to improve muscle growth, red blood cell production, increase bone density and stimulate the appetite of debilitated or weakened animals. Stanozolol is one of the Anabolic steroids commonly used as an ergogenic aid and is banned from use in sports competition under the auspices of the International Association of Athletics Federations (IAAF). Used illegally in bodybuilding, typically "stacked" with other testosterone-based anabolic steroids. Stanozolol is liked by many due to the fact it causes strength increases without excess weight-gain, promotes increases in vascularity, and will not convert to estrogen. It also does not cause excess water retention, and even sometimes is thought to have a diuretic effect on the body. Stanozolol is commonly used by athletes and bodybuilders alike to lose fat while retaining lean body mass. It is usually used in a cutting cycle, to help preserve lean body mass while metabolizing adipose, although it has not been proven conclusively that it has any special fat-burning properties. It is presented most commonly as a 50 mg/mL injection or a 50 mg tablet. However, recently 100 mg/mL versions have become available. A common dosage can be 25-100 mg/day, with optimal results usually seen at 50 mg/day. It is reduced to micrometer particles in aqueous suspension and does not have a typical elimination half-life. Authentic Stanozol can easily be seen, because it will separate in its container if left undisturbed for a number of hours (the micronized crystal will fall to the bottom, and the water suspension will rise to the top). It has a white, milky colour. It should be taken no more than 48 hours apart, with some users preferring to inject every day, or even twice a day, to maintain serum levels. The drug has been known to cause masculinising side-effects in women with doses as low as 2 mg per day, and liver damage has been known to occur with extended usage of larger doses. An alternative to Stanzolol is Furazabol. Furazabol's effects are virtually identical to Stanzolol except that instead of having an extremely adverse effect on cholesterol values, Furazabol actually improves a person's blood lipid profile.[citation needed] Sold under the trade name Mitolan, Furazabol is a standard treatment in Japan for hyperlipemia.

Anabolic and virilizing effects

2007-09-27T04:54:00.001-07:00

Anabolic and virilizing effects

2007-09-26T03:18:00.000-07:00

Deca-Durabolin ( Nandrolone )

2007-09-25T03:41:00.001-07:00

Stanozolol - winstrol

2007-09-24T10:23:00.001-07:00

Stanozolol - winstrol
Stanozolol, commonly sold under the name Winstrol (oral) and Winstrol Depot (intra-muscular), was developed by Winthrop Laboratories in 1962. It is a synthetic anabolic steroid derived from testosterone, and has been approved by the FDA for human use. Unlike most injectable anabolic steroids, Stanozolol is not esterified and is sold as an aqueous suspension, or in oral tablet form. The drug has a large oral bioavailability, due to a C17 α-alkylation which allows the hormone to survive first pass liver metabolism when ingested. It is because of this that Stanozolol is also sold in tablet form. Stanozolol has been used on both animal and human patients for a number of conditions. In humans, it has been demonstrated to be successful in treating anaemia and hereditary angioedema. Veterinarians may prescribe the drug to improve muscle growth, red blood cell production, increase bone density and stimulate the appetite of debilitated or weakened animals. Stanozolol is one of the Anabolic steroids commonly used as an ergogenic aid and is banned from use in sports competition under the auspices of the International Association of Athletics Federations (IAAF). Used illegally in bodybuilding, typically "stacked" with other testosterone-based anabolic steroids. Stanozolol is liked by many due to the fact it causes strength increases without excess weight-gain, promotes increases in vascularity, and will not convert to estrogen. It also does not cause excess water retention, and even sometimes is thought to have a diuretic effect on the body. Stanozolol is commonly used by athletes and bodybuilders alike to lose fat while retaining lean body mass. It is usually used in a cutting cycle, to help preserve lean body mass while metabolizing adipose, although it has not been proven conclusively that it has any special fat-burning properties. It is presented most commonly as a 50 mg/mL injection or a 50 mg tablet. However, recently 100 mg/mL versions have become available. A common dosage can be 25-100 mg/day, with optimal results usually seen at 50 mg/day. It is reduced to micrometer particles in aqueous suspension and does not have a typical elimination half-life. Authentic Stanozol can easily be seen, because it will separate in its container if left undisturbed for a number of hours (the micronized crystal will fall to the bottom, and the water suspension will rise to the top). It has a white, milky colour. It should be taken no more than 48 hours apart, with some users preferring to inject every day, or even twice a day, to maintain serum levels. The drug has been known to cause masculinising side-effects in women with doses as low as 2 mg per day, and liver damage has been known to occur with extended usage of larger doses. An alternative to Stanzolol is Furazabol. Furazabol's effects are virtually identical to Stanzolol except that instead of having an extremely adverse effect on cholesterol values, Furazabol actually improves a person's blood lipid profile.[citation needed] Sold under the trade name Mitolan, Furazabol is a standard treatment in Japan for hyperlipemia.

Oxandrolone (Oxandrin) - ANAVAR

2007-09-21T05:17:00.000-07:00

Methenolone Enanthate - Primobolan

2007-09-20T20:22:00.001-07:00

Methenolone Enanthate is a DHT based anabolic steroid. Sold commonly under the brand name of Primobolan® (tablet form) or Primobolan® Depot (injectable).
When it interacts with the aromatase enzyme it does not form any estrogens. It is used by people who are very succeptible to estrogenic side effects, having lower estrogenic properties than Nandrolone. Methenolone is available as an injection or as an oral. The injection is naturally regarded as having a higher bioavailability. Its an enanthate ester which is quite long-acting. Because it by-passes hepatic breakdown on the first pass, it also has a higher survival rate. The tablets are in a short-lived acetate form. Methenolone is not 17-alpha-alkylated, but 1-methylated for oral bioavailability. This reduces the stress on the liver, but also the availability. It is considered one of the safer steroids, meaning it has a very little side effects. Methenolone has no estrogenic side effects, and its effects on cholesterol levels are minimal. In doses of 200 mg or less (intramuscular) blood pressure is rarely altered.
Possibly one of the safer anabolic steroids for females due to very low virilization effects in short-term usage. Of course, this is not a blanket-statement and individual results (dependent on doses and tolereance) will vary.
Methenolone is also not overly suppressive of the HPTA axis, although how suppressive is debatable. For this reason, many bodybuilders use it in between steroid cycles during their "off-time" to help maintain their gains and strength. The long term safety of such a practice possibly dangerous and can lead to permanent suppression of the HPTA.
Arnold Schwarzenegger is rumored to have introduced methenolone to the US bodybuilding community

THG Steroids by Balco

2007-09-19T03:59:00.001-07:00

THG Steroids by Balco

Deca-Durabolin ( Nandrolone )

2007-09-18T20:14:00.000-07:00

Nandrolone is an anabolic steroid occurring naturally in the human body, albeit in small quantities. Nandrolone is most commonly sold commercially as its decanoate ester (Deca-Durabolin) and less commonly as a phenylpropionate ester (Durabolin). Nandrolone use is indirectly detectable in urine tests by testing for the presence of 19-norandrosterone, a metabolite of this molecule. The International Olympic Committee has set a limit of 2 ng per ml of urine as the upper limit, beyond which an athlete is suspected of doping.
Contents [hide]1 Detection Methods 2 Metabolism 3 Controversial abuse cases 4 External Links
Detection MethodsUrine analysis as a method of detecting nandrolone abuse has recently become somewhat controversial, following studies by the University of Aberdeen showing that the metabolite product can also show up in urine in quantities above the upper limit from a combination of high-protein diets utilising the legal nutritional supplement creatine and hard cardiovascular exercise. The reason for this unexpected result has not been determined. Another possible (though unlikely) reason for a false positive result is the consumption of beef from cattle treated with steroids including nandrolone (used in overturning the verdict against the bobsleigh racer, Lenny Paul). Heavy consumption of the essential amino acid lysine (as indicated in the treatment of cold sores) has also shown false positives in some and was cited by American Shotputter C.J. Hunter as the reason for his positive test. A final possible cause of incorrect urine test results is the presence of metabolites from other anabolic steroids. However, as all such substances are also banned, this source is somewhat insignificant when interpreting the results of such a test. As a result of the numerous overturned verdicts, the testing procedure was reviewed by UK Sport [1] in 2000.
Metabolism Nandrolone binds to the androgen receptor to a greater degree than testosterone, but due to its inability to act on the muscle in ways unmediated by the receptor, has less overall effect on muscle growth. The drug is also unusual in that unlike most anabolic steroids, it is not broken down into the more reactive DHT by the enzyme 5α-reductase, but rather into a less effective product. As such, some of the negative effects associated with most such drugs are somewhat mitigated.
The positive effects of the drug include muscle growth, appetite stimulation and increased red blood cell production and bone density. Clinical studies have shown it to be effective in treating anaemia, osteoporosis and some forms of neoplasia including breast cancer, and also acts as a progestin-based contraceptive. For these reasons, nandrolone received FDA approval in 1983, and while sale is now restricted by the Controlled Substances Act, it remains available by prescription in most countries. In addition to legal production, Nandrolone is also extensively produced and used by athletes and bodybuilders seeking an edge in professional competition.
Because nandrolone is not broken down into DHT, the deleterious effects common to most anabolic steroids on the scalp, skin, and prostate are lessened to a degree. The lack of alkylation on the 17α-carbon drastically reduces the drug's liver toxicity. Estrogenic effects resulting from reaction with aromatase are also mitigated as a result of the drug being a progestin, but effects such as gynaecomastia and reduced libido still occur in larger doses. Other side-effects can include erectile dysfunction and cardiovascular damage, as well as several ailments resulting from the drug's effect of lowering levels of luteinizing hormone through negative feedback.
Controversial abuse cases QV Nandrolone Deca, a form of nandrolone used by atheletes

Shoaib Akhtar, Pakistani cricketer (Did not contest presence of nandrolone in sample but was cleared of intentionally taking nandrolone by the Pakistan Cricket Board. WADA guidelines state that ignorance of substances an athlete has in his body is not a valid defence unless the athlete can clearly prove "no fault or negligence". Despite Akhtar neither demonstrating such nor providing any of the supposedly contaminated supplements which were to blame, the PCB overturned the two-year ban imposed. WADA is currently appealing the case to the Court of Arbitration for Sport.) Mohammad Asif, Pakistani cricketer (Did not contest presence of nandrolone in sample but was cleared of intentionally taking nandrolone by the Pakistan Cricket Board. WADA guidelines state that ignorance of substances an athlete has in his body is not a valid defence unless the athlete can clearly prove "no fault or negligence". Despite Asif neither demonstrating such nor providing any of the supposedly contaminated supplements which were to blame and admitting that he had received multiple injections which he did not know the contents of, the PCB overturned the one-year ban imposed. WADA is currently appealing the case to the Court of Arbitration for Sport.) Dieter Baumann, German long-distance runner Bryan Berard, American ice hockey player Linford Christie, British sprinter Edgar Davids, Dutch football player Christophe Dugarry, French football player Jason Giambi, American baseball player Latasha Jenkins, American sprinter Sesil Karatantcheva, Bulgarian tennis player Petr Korda, Czech tennis player Shawne Merriman, San Diego Chargers Linebacker Halil Mutlu, Turkish weight lifter Merlene Ottey, Jamaican 200m sprint World Champion Nuno Assis, (Portugal) SL Benfica Midfielder Lenny Paul, British bobsleigh racer Mark Richardson, British sprinter Orlando Salido, Mexican boxer James Toney, American boxer Craig Trindall, Australian rugby league player Dougie Walker, British sprinter

Deca-Durabolin ( Nandrolone )

2007-09-16T22:09:00.000-07:00

Nandrolone is an anabolic steroid occurring naturally in the human body, albeit in small quantities. Nandrolone is most commonly sold commercially as its decanoate ester (Deca-Durabolin) and less commonly as a phenylpropionate ester (Durabolin). Nandrolone use is indirectly detectable in urine tests by testing for the presence of 19-norandrosterone, a metabolite of this molecule. The International Olympic Committee has set a limit of 2 ng per ml of urine as the upper limit, beyond which an athlete is suspected of doping.
Contents [hide]1 Detection Methods 2 Metabolism 3 Controversial abuse cases 4 External Links
Detection MethodsUrine analysis as a method of detecting nandrolone abuse has recently become somewhat controversial, following studies by the University of Aberdeen showing that the metabolite product can also show up in urine in quantities above the upper limit from a combination of high-protein diets utilising the legal nutritional supplement creatine and hard cardiovascular exercise. The reason for this unexpected result has not been determined. Another possible (though unlikely) reason for a false positive result is the consumption of beef from cattle treated with steroids including nandrolone (used in overturning the verdict against the bobsleigh racer, Lenny Paul). Heavy consumption of the essential amino acid lysine (as indicated in the treatment of cold sores) has also shown false positives in some and was cited by American Shotputter C.J. Hunter as the reason for his positive test. A final possible cause of incorrect urine test results is the presence of metabolites from other anabolic steroids. However, as all such substances are also banned, this source is somewhat insignificant when interpreting the results of such a test. As a result of the numerous overturned verdicts, the testing procedure was reviewed by UK Sport [1] in 2000.
Metabolism Nandrolone binds to the androgen receptor to a greater degree than testosterone, but due to its inability to act on the muscle in ways unmediated by the receptor, has less overall effect on muscle growth. The drug is also unusual in that unlike most anabolic steroids, it is not broken down into the more reactive DHT by the enzyme 5α-reductase, but rather into a less effective product. As such, some of the negative effects associated with most such drugs are somewhat mitigated.
The positive effects of the drug include muscle growth, appetite stimulation and increased red blood cell production and bone density. Clinical studies have shown it to be effective in treating anaemia, osteoporosis and some forms of neoplasia including breast cancer, and also acts as a progestin-based contraceptive. For these reasons, nandrolone received FDA approval in 1983, and while sale is now restricted by the Controlled Substances Act, it remains available by prescription in most countries. In addition to legal production, Nandrolone is also extensively produced and used by athletes and bodybuilders seeking an edge in professional competition.
Because nandrolone is not broken down into DHT, the deleterious effects common to most anabolic steroids on the scalp, skin, and prostate are lessened to a degree. The lack of alkylation on the 17α-carbon drastically reduces the drug's liver toxicity. Estrogenic effects resulting from reaction with aromatase are also mitigated as a result of the drug being a progestin, but effects such as gynaecomastia and reduced libido still occur in larger doses. Other side-effects can include erectile dysfunction and cardiovascular damage, as well as several ailments resulting from the drug's effect of lowering levels of luteinizing hormone through negative feedback.
Controversial abuse cases QV Nandrolone Deca, a form of nandrolone used by atheletes

Shoaib Akhtar, Pakistani cricketer (Did not contest presence of nandrolone in sample but was cleared of intentionally taking nandrolone by the Pakistan Cricket Board. WADA guidelines state that ignorance of substances an athlete has in his body is not a valid defence unless the athlete can clearly prove "no fault or negligence". Despite Akhtar neither demonstrating such nor providing any of the supposedly contaminated supplements which were to blame, the PCB overturned the two-year ban imposed. WADA is currently appealing the case to the Court of Arbitration for Sport.) Mohammad Asif, Pakistani cricketer (Did not contest presence of nandrolone in sample but was cleared of intentionally taking nandrolone by the Pakistan Cricket Board. WADA guidelines state that ignorance of substances an athlete has in his body is not a valid defence unless the athlete can clearly prove "no fault or negligence". Despite Asif neither demonstrating such nor providing any of the supposedly contaminated supplements which were to blame and admitting that he had received multiple injections which he did not know the contents of, the PCB overturned the one-year ban imposed. WADA is currently appealing the case to the Court of Arbitration for Sport.) Dieter Baumann, German long-distance runner Bryan Berard, American ice hockey player Linford Christie, British sprinter Edgar Davids, Dutch football player Christophe Dugarry, French football player Jason Giambi, American baseball player Latasha Jenkins, American sprinter Sesil Karatantcheva, Bulgarian tennis player Petr Korda, Czech tennis player Shawne Merriman, San Diego Chargers Linebacker Halil Mutlu, Turkish weight lifter Merlene Ottey, Jamaican 200m sprint World Champion Nuno Assis, (Portugal) SL Benfica Midfielder Lenny Paul, British bobsleigh racer Mark Richardson, British sprinter Orlando Salido, Mexican boxer James Toney, American boxer Craig Trindall, Australian rugby league player Dougie Walker, British sprinter

Anabolic and virilizing effects

2007-09-16T21:34:00.001-07:00

Anabolic androgenic steroids produce both anabolic and virilization (also known as androgenic) effects. Most anabolic steroids work in two simultaneous ways. First, they work by binding the androgen receptor and increasing protein synthesis. Second, they also reduce recovery time by blocking the effects of the stress hormone, cortisol, on muscle tissue. As a result, catabolism of the body's muscle mass is greatly reduced.
Examples of anabolic effects:
Increased protein synthesis from amino acids Increased muscle mass and strength[4][5][6] Increased appetite Increased bone remodeling and growth Stimulation of bone marrow increasing production of red blood cells Examples of virilizing/androgenic effects:
Growth of the clitoris (clitoral hypertrophy) in females and the penis in male children (the adult penis does not grow indefinitely even when exposed to high doses of androgens) Increased growth of androgen-sensitive hair (pubic, beard, chest, and limb hair) Increased vocal cord size, deepening the voice Increased libido Suppression of endogenous sex hormones Impaired spermatogenesis

Anabolic and virilizing effects

2007-09-16T21:34:00.000-07:00

Anabolic and virilizing effects

2007-09-13T20:06:00.000-07:00

Oxandrolone (Oxandrin) - ANAVAR

2007-09-13T01:10:00.000-07:00

Deca-Durabolin ( Nandrolone )

2007-09-11T10:01:00.000-07:00

Anabolic and virilizing effects

2007-09-09T22:18:00.000-07:00

Oxandrolone (Oxandrin) - ANAVAR

2007-09-07T03:33:00.000-07:00

THG Steroids by Balco

2007-09-04T09:08:00.001-07:00

THG Steroids by Balco

2007-09-03T05:22:00.000-07:00

THG Steroids by Balco

Oxandrolone (Oxandrin) - ANAVAR

2007-08-31T04:38:00.001-07:00

Anabolic and virilizing effects

2007-08-30T04:08:00.000-07:00

Testosterone cypionate

2007-08-29T04:12:00.000-07:00

Testosterone cypionate

Quick overview:

Active Life: 15-16 days
Drug Class: Anabolic/Androgenic Steroid (for injection)
Average Dose: Men 250-1000 mg/week
Acne: Yes
Water Retention: Yes, high
High Blood Pressure: Yes
Liver Toxic: Low, except in mega dosages
Aromatization:Yes, high
DHT Conversion: Yes, high
Decrease HPTA function: Yes, severe

American athletes have a long and fond relationship with Testosterone cypionate. While Testosterone enanthate is manufactured widely throughout the world, cypionate seems to be almost exclusively an American item. It is therefore not surprising that American athletes particularly favor this testosterone ester. But many claim this is not just a matter of simple pride, often swearing cypionate to be a superior product, providing a bit more of a "kick" than enanthate. At the same time it is said to produce a slightly higher level of water retention, but not enough for it to be easily discerned. Of course when we look at the situation objectively, we see these two steroids are really interchangeable, and cypionate is not at all superior. Both are long acting oil-based injectables, which will keep testosterone levels sufficiently elevated for approximately two weeks. Enanthate may be slightly better in terms of testosterone release, as this ester is one carbon atom lighter than cypionate (remember the ester is calculated in the steroids total milligram weight). The difference is so insignificant however that no one can rightly claim it to be noticeable (we are maybe talking a few milligrams per shot). Regardless, cypionate came to be the most popular testosterone ester on the U.S. black market for a very long time

As with all anabolic steroids testosterone injectables, one can expect a considerable gain in muscle mass and strength during a cycle. Since testosterone readliy converts to estrogen, the mass gained from this drug is likely to be accompanied by quite a bit of water retention. The resulting loss of definition of course makes cypionate a very poor choice for dieting or cutting phases. The excess level of estrogen brought about by this drug can also cause one to develop gynecomastia rather quickly. Should one notice an uncomfortable soreness, swelling or lump under the nipple, an ancillary drug like Nolvadex should be added immediately. This will minimize the effect of estrogen greatly, making the steroid much more tolerable to use. The powerful anti-aromatases Arimidex, Femara, or Aromasin are yet a better choice. Those who have a known sensitivity to estrogen may find it more beneficial to use ancillary drugs like Nolvadex and Proviron from the onset of the cycle, in order to prevent estrogen related side effects before they become apparent.

Since testosterone is the primary male androgen, we should also expect to see pronounced androgenic side effects with this drug. Much intensity is related to the rate in which the body converts testosterone into dihydrotestosterone (DHT). This, as you know, is the devious metabolite responsible for the high prominence of androgenic side effects associated with testosterone use. This includes the development of oily skin, acne, body/facial hair growth and male pattern balding. Those worried that they may have a genetic predisposition toward male pattern baldness may wish to avoid testosterone altogether. Others opt to add the ancillary drug Proscar/Propecia, that prevents the conversion of testosterone to dihydrotestosterone. This can greatly reduce the chance for running into a hair loss problem, and will probably lower the intensity of other androgenic side effects. Although active in the body for much longer time, cypionate is injected on a weekly or bi-weekly basis in order to maintain stable blood levels. At a dosage of 250mg to 800mg per week we should certainly see dramatic results. It is interesting to note that while a large number of other steroidal compounds have been made available since testosterone injectables, they are still considered to be the dominant bulking agents among bodybuilders. There is little argument that these are among the most powerful mass drugs. When taking dosages above 800-1000mg per week there is little doubt that water retention will come to be the primary gain, far outweighing the new mass accumulation. The practice of "megadosing" is therefore inefficient, especially when we take into account the typical high cost of steroids today.

It is also important to remember that the use of an injectable testosterone will quickly suppress endogenous testosterone production. It is therefore mandatory to complete a proper post cycle therapy, constisting of HCG and Clomid or Nolvadex at the conclusion of a cycle. This should help the user avoid a strong "crash" due to hormonal imbalance, which can strip away much of the new muscle mass and strength. This is no doubt the reason why many athletes claim to be very disappointed with the final result of steroid use, as there is often only a slight permanent gain if anabolics are discontinued incorrectly. Of course we cannot expect to retain every pound of new bodyweight after a cycle. This is especially true whenever we are withdrawing a strong (aromatizing) androgen like testosterone, as a considerable drop in weight (and strength) is to be expected as retained water is excreted. This should not be of much concern; instead the user should focus on ancillary drug therapy so as to preserve the solid mass underneath. Another way athletes have found to lessen the "crash", is to first replace the testosterone with a milder anabolic like Deca-Durabolin. This steroid is administered alone, at a typical dosage (200-400mg per week), for the following month or two. In this "stepping down" procedure the user is attempting to turn the watery bulk of a strong testosterone into the more solid muscularity we see with nandrolone preparations. In many instances this practice proves to be very effective. Of course we must remember to still administer ancillary drugs at the conclusion, as endogenous testosterone production will not be rebounding during the Deca therapy.

Stallone Convicted of Possession of Steroids

2007-08-28T20:25:00.000-07:00

Stallone Convicted of Possession of Steroids
Rocky star was caught by customs agents trying to take steroids to Australia.
Sylvester Stallone was formally convicted in Australian court on charges of importing restricted muscle-building growth hormones into the country, and ordered to pay $10,000 in fines, $2,451 for his guilty plea and a further $8,200 to cover prosecution costs.
The hormones, 45 vials of Jintropin and four vials of testosterone, were found by customs agents when the actor was arriving in Australia in February for Rocky VI press duties. "This stuff gives your body a boost and you feel and look good," he said, per the customs report. "Doing Rambo is hard work, and I am going to be in Burma for a while. Where do you think I am going to get this stuff in Burma?"
Although Stallone said to customs officers that his Los Angeles doctor had prescribed the hormones to treat an undisclosed malady, that doesn’t explain why he tried to hurl the bottles of testosterone out of the window when the officers showed up to search his hotel room.
"The accused came into this country as a visitor; all visitors are welcome as long as they obey the law," Deputy Chief Magistrate Paul Cloran said. "Mr. Stallone made an error of judgment and he has apologized...with the plea of guilty he has done all he could to remedy the situation."

Oxandrolone (Oxandrin) - ANAVAR

2007-08-27T09:18:00.001-07:00

Oxandrolone (Oxandrin) is an anabolic steroid created by Searle Laboratories under the trademark Anavar, and introduced into the US in 1964. It is taken orally, and unlike other steroids delivered in this manner, most of which are Class II steroids, the majority of its effects are due to reaction with the androgen receptor. In sufficient dosage, Oxandrolone is highly likely to bind well with the receptor, and is therefore a Class I steroid, while having few other side-effects.
The drug was prescribed for a number of medical disorders causing involuntary weight loss, in order to promote muscle regrowth. It had also been shown to be partially successful in treating cases of osteoporosis. However, in part due to bad publicity from its illegal use by bodybuilders, Oxandrolone was discontinued by Searle Laboratories in 1989. It was picked up by Bio-Technology General Corporation who, following successful clinical trials in 1995, released it under the tradename Oxandrin. It was approved for orphan drug status by the Food and Drug Administration (FDA) in treating alcoholic hepatitis, Turner's syndrome, and weight loss caused by HIV. In addition, the drug has shown positive results in treating anaemia and hereditary angioedema. Clinical studies however have shown links between prolonged use of the drug and problems of liver toxicity similar to those found with other 17α-alkylated steroids. Even in small dosages, many users reported gastro-intestinal problems such as bloating, nausea, and diarrhoea.
Before the Controlled Substances Act was passed to restrict the production, sale, and usage of anabolic steroids, Oxandrolone's characteristics lent itself well towards use by female athletes. Its specificity targeting the androgen receptor meant that, unlike many other steroids, it had not been reported to cause stunted growth in younger users, and at typical dosage rarely caused noticeable masculinising effects outside of stimulating muscle growth. In addition, Oxandrolone does not aromatise at any dosage, and is not easily metabolised into DHT or oestrogen. As such, a typical dose of 20-30 mg provided elevated androgen levels for up to eight hours. To increase effectiveness, bodybuilders typically "stacked" the drug with others such as Testosterone, further enhancing body mass gain.

Stallone Convicted of Possession of Steroids

2007-08-24T07:57:00.000-07:00

Stanozolol - winstrol

2007-08-23T03:06:00.000-07:00

Oxandrolone (Oxandrin) - ANAVAR

2007-08-22T01:54:00.000-07:00

Anabolic and virilizing effects

2007-08-21T02:23:00.000-07:00

Trenbolone

2007-08-20T09:22:00.000-07:00

Trenbolone is an anabolic steroid used by veterinarians on livestock to increase muscle growth and appetite. To increase its effective half-life, trenbolone is not used in an unrefined form, but is rather administered as trenbolone acetate (Finaplix Gold from Valopharm USA, TREMBLONA QV75 from Quality Vet, Mexico), trenbolone enanthate or trenbolone cyclohexylmethylcarbonate (Parabolan from Laboratoires NEGMA until 1997). Trenbolone is then produced as a metabolite by the reaction of these compounds with the androgen receptor.[citation needed]

Illicit UseNo trenbolone compounds have been approved by the FDA for human use, due to a lack of clinical applications and considerable negative side-effects.[citation needed] It is classified as a Schedule III drug under the Controlled Substances Act. However, bodybuilders have been known to use the drug illicitly in order to increase body mass more effectively than by weight training alone. A normal bodybuilding dosage can range from 200 mg/week up to 1400 mg/week. Due to the relatively short metabolic half-life of trenbolone acetate, dosages should commonly be split into injections at least once every two days. Trenbolone enanthate can be injected once a week.
The 2006 book Game of Shadows alleges that baseball superstar Barry Bonds used this drug in 2001, when he set the current single-season home run record.
Trenbolone compounds have a binding affinity for the androgen receptor three times as high as that of testosterone.[citation needed] Once metabolised, the drugs have the effect of increasing nitrogen uptake by muscles, leading to an increase in the rate of protein synthesis. It also has the secondary effects of stimulating appetite, reducing the amount of fat being deposited in the body, and decreasing the rate of catabolism. Trenbolone has proven popular with anabolic steroid users as it is not metabolised by aromatase or 5α-reductase into estrogenic compounds such as estradiol, or into DHT. This means that it also does not cause any water retention normally associated with highly androgenic steroidal compounds like testosterone or methandrostenolone. It is also loved by many for the dramatic strength increases commonly experienced with it. Some short-term side effects include insomnia, high blood pressure, increased aggression and libido. However, since women will suffer virilization effects even at small doses, this drug should not be taken by a female. Urban wisdom/myth in bodybuilding culture, states that the use of the drug over extended periods of time can lead to kidney damage. The kidney toxicity has not yet been proven, and scientific evidence supporting the idea is suspiciously absent from the bodybuilding community that perpetuates this idea. The origin of this myth most likely has to do with the rust colored oxidized metabolites of trenbolone which are excreted in urine and often mistaken for blood. After Schänzer (Clin Chem 1996; 42(7): 1001-1020, Metabolism of anabolic androgenic steroids) trenbolone and 17epi-trenbolone are both excreted (in urine) as conjugates that can be hydrolyzed with beta-glucuronidase. This implies that trenbolone leaves the body as beta-glucuronides or sulfates, that means mostly non metabolized.

Anabolic and virilizing effects

2007-08-17T21:13:00.000-07:00

steroids

2007-08-17T20:50:00.000-07:00

A steroid is a terpenoid lipid characterized by a carbon skeleton with four fused rings. Different steroids vary in the functional groups attached to these rings. Hundreds of distinct steroids have been identified in plants, animals, and fungi. All steroids are derived either from the sterol lanosterol (animals and fungi) or the sterol cycloartenol (plants). Both sterols are derived from the cyclization of the triterpene squalene[1].

Anabolic steroids are a class of steroids that interact with androgen receptors to increase muscle and bone synthesis. There are natural and synthetic anabolic steroids. These are the "steroids" used by athletes to increase performance.

Anabolic and virilizing effects

2007-08-16T22:31:00.000-07:00

Dianabol (methandrostenolone)

2007-08-15T21:35:00.001-07:00

Dianabol (methandrostenolone)

2007-08-15T21:35:00.000-07:00

Anadrol - Oxymetholone

2007-08-15T00:08:00.000-07:00

Oxymetholone (Anadrol), is a synthetic anabolic steroid developed by Syntex in 1960. Its primary clinical applications include treatment of osteoporosis and anaemia, as well as stimulating muscle growth in undernourished or underdeveloped patients. The drug was approved for human use by the FDA. However, later non-steroidal drugs such as Epogen were developed and proven to be more effective as a treatment for anaemia and osteoporosis without the side-effects of oxymetholone. The drug remained available despite this, and eventually found a new use in treating HIV wasting syndrome. While classified as a Schedule III drug under the Controlled Substances Act, it remains available via prescription as Anadrol (registered as a trademark of Unimed Pharmaceuticals.)

Presented most commonly as a 50 mg tablet, Oxymetholone is the strongest androgenic steroid available. Similarly, it also poses the greatest risk of side effects of any steroid. Despite very low binding affinity with the androgen receptor, oxymetholone is highly effective in promoting extensive gains in body mass, mostly by greatly improving protein synthesis. For this reason, it is often used illegally by bodybuilders and athletes. Many athletes also use Oxymetholone as a method of protection for the joints under heavy loads. Due to the high water retention users experience from this drug, it similarly lubricates the joints and helps protect them from injury. Oxymetholone is widely considered by bodybuilders to have the strongest anabolic effect out of any oral steroid available; weight increases of 20 pounds in 2 weeks are not unusual of with this drug.

Side effects
The side-effects of short-term use of the drug itself include nausea, bloating, acne, and masculinising effects such as deepening of the voice, growth of facial hair and clitoral hypertrophy . In addition, oxymetholone is readily aromatized by aromatase to form a progestagen, and unless selective estrogen receptor modulators such as tamoxifen or clomifene are taken in conjunction with the drug, there is a significant risk of the appearance of estrogenic effects such as gynaecomastia over time. Because of its 17α-alkylated structure, oxymetholone is highly hepatotoxic. Long term use of the drug can cause a variety of serious ailments, including hepatitis, liver cancer, and cirrhosis. It is very dangerous to take oxymetholone in high dosages for periods of time exceeding six weeks, and is commonly used by bodybuilders during the start of a steroid cycle to help gain mass and increase serum levels of androgens quickly.

Use with other steroids
To further increase its effectiveness as an anabolic agent, bodybuilders typically stack (see steroid stack) oxymetholone with other anabolic steroids. Since it is already a very potent androgen, many users will combine it with drugs such as nandrolone, boldenone and testosterone to further their gains.

Stallone Convicted of Possession of Steroids

2007-08-13T23:08:00.001-07:00

Stallone Convicted of Possession of Steroids

2007-08-12T21:46:00.000-07:00

Oral-Turinabol

2007-08-10T22:56:00.001-07:00

Oral-Turinabol

Oral Turinabol was first developed by scientists in East Germany for their Olympic and national-level athletes to use. This, plus the eventual removal of it from the market caused OT to become a very "sexy" drug for athletes to try and obtain. The East Germans studied this drug pretty extensively for many years and some of the success of this now defunct country was attributed to this drug, which made it´s first appearance to athletes in East Germany as little blue "Vitamins" their coaches gave to them. This anabolic steroids drug has been discontinued by all of the major pharmaceutical houses, and is only found through certain underground labs. Even though some UnderGround Labs have access to this item, and it appears on their price-lists, it´s still rare enough. I believe it was first produced in the last half decade by a certain cat in Thailand. It´s my speculation that it´s on the cusp of either becoming very popular, to the point where every Underground Lab will start carrying their own version of it, or it will disappear again and only be carried by a select few, if any, suppliers.

The easiest way to explain this drug is that it is a derivative of Dianabol. Though it is a derivative of our old friend Diana, it´s still quite different...remember, Equipoise is estrified Dianabol, and really has nothing in common with it, in terms of real-world-effects. Let´s examine OT in relation to D-bol for now, though. The first similarity between the two is that they have both been 17-alpha-alkylated (a carbon atom was added at the 17th position) to survive the first pass through the liver. This, of course, increases hepatoxicity (liver toxicity). OT has a much lower level of androgenic activity compared to dianabol, but a better balance/ratio of anabolic and androgenic effects. It has a rating of a 0 (according to the Vida reference) for androgenic properties and a 53 for anabolic properties based on a score of 100 each for testosterone. This promotes more of a "hard" look, of what competition bodybuilders often call "quality" muscle. You do not get the same "puffy" look as you would on d-bol, and many people have thus compared the results they´ve gotten from OT to Anavar. Actually, though, this stuff is simply dianabol with a 4-chloro alteration, the same alteration found in Clostebol.

Due to this 4-chloro substitution in the A-Ring of its Steran Nucleus, this drug cannot be aromatized (3). This is, as you know, quite beneficial and is one of the reasons Oral Turinabol has been called a "gentle d-bol." You will probably not get any typical estrogenic side effects like water retention, acne, gyno, etc, at any dose of this drug. A couple of studies I read examining male athletes over a period of six weeks were given 10 mg OT/day did not show any indications of health-threatening effects. It has been recommended that men should take between 20-40mg every day and women a 5mg every day, and I generally think that it is not very strong (as compared to many other orals) and wouldn´t drop below the 40mg mark if I were to use it personally. It may perhaps be used in low(er) doses if it is simply being used for it´s ability to reduce SHBG´s binding (1) to other steroids. In this respect, it may have synergy with other drugs, since it has the ability to reduce SHBG and thus free up more testosterone for use in your body.

The only negative thing I have heard about this drug is that in high doses (10+mg) virilization has been seen in women(14) and there has been at least one case of testicular tumors, and one case of a guy who suffered adverse effects from 5 years of high-dose use of OT (2)(4). It should be noted that the former East Germans did many experiments with this drug in high doses though, and found it to be a very suitable compound for their athletes. Many of the women suffered virilization at higher doses, though. During the 68-72 Olympic cycles, the East German Sports OT program made its biggest impact. It was around this time, that the East German weightlifters were taking over 10g/year of OT, and their leading male sprinter was taking under 730mgs/year of OT (14). I think this tells me that for real weight gains, and huge gains in the weight room, you´re going to need bank-breaking dosages of this stuff. On the bright side, if you are an athlete looking to get faster, a little bit of OT will get you there pretty easily, and with minimal (if any) side effects). I think that it´s inability to cause negative side effects, and it´s ability to produce a favorable increase in lean body mass and thus a favorable increase in strength/speed and an athlete´s strength:bodyweight ratio is what turned the East German coaches and scientists on. It must be noted that, at the time, this stuff was mostly undetectable, and that was certainly a sought after trait by the East Germans, who were looking to circumvent the drug testing procedures of the IOC. Now, of course, OT is detectable, as once it´s administered to man, three major metabolites are formed: 6 beta-hydroxy-turinabol, 6 beta, 12-dihydroxy-turinabol, and 6 beta, 16-dihydroxy-turinabol (5)(8)(9).All of those metabolites are now detectable by drug screeners. In much smaller quantities at least another three metabolites are excreted, one of which could be identified as 17 epi-turinabol (5), and is easily detected by modern drug tests... No measurable amounts of OT itself is detected in any of the urine samples investigated in sports doping procedures, but the presence of the metabolites is enough to warrant a positive result, and a failed test. Keeping all of this in mind, it is still important to note that the rate of metabolism and urinary excretion or Oral Turinabol is reasonably fast (5), even though it is technically eliminated biphastically (in two stages) by the body, with a terminal 16hr ½ life (1). I think that the sports-doping-party-poopers (The NCAA and IOC) OT is notorious for increasing the time it will take for your blood to clot because it has spontaneous fibrinolytic properties. "Fibrinolytic effects" means that the destruction of fibrin (an insoluble fibrous protein produced in the liver from the soluble protein) is happening in your body. Fibrinogen is important during the blood clotting process, as it is a soluble protein in the blood that is converted to insoluble fibrin by the action of the enzyme thrombin in response to tissue damage. (6)(7) Thus, you will bleed for longer than usual when on this stuff, combine that with the fact that steroids raise your hematocrit and you´ll be spending your entire morning trying to stop the bleeding if you cut yourself shaving. Well, that´s probably an exaggeration, but not by much.

Oral Turinabol Olympic Cycle
I´ve already told you that this stuff is a potent lean tissue builder, and good for cutting. But that´s mostly of interest for bodybuilders. Now, with regards to athletics, what kind of results can we expect? Well, I was digging through the old East German literature, and found that they reported that their world class strength athletes were making some pretty remarkable improvements on OT, over a 4 year Olympic training period: Male Shot-putters were adding 2.5-4m to their shot throws, 10-12m on their Discus throw, and 6-10m to their Hammer throws. Female athletes gained even more. Lets take a look at a chart representing the improvements made by one particular female strength athlete (*she held the World Record for the shot put, at the time of her beginning OT administration), over a the period of July 18th 1968 through October 13th 1972. During the time she was taking OT, she improved her throw from under 18m to over 20m (yes, this is a 2m+ improvement, to a world record holding throw, in one Olympic Cycle). She was taking roughly 5-15mgs/day of OT in the beginning, but worked up to 35mgs/day before she was done with her Olympic cycle. Her throws even while "off" OT even improved a bit, leading to speculation that there are a lot of permanent gains to be had with OT. Anyway, here are the charts representing her intake of OT, as well as her improvements over her 4 year over her 4 year Olympic training regimen:

Effects of an androgenic-anabolic steroid, Oral-Turinabol, on the shot-put performance (in meters, y-axis) of a female athlete (code identification 1/68 in a, 1/69 in b, and 1/72 in c) directly photographed from the secret scientific report of Bauersfeld et al. (13), as one of the numerous examples documented, chosen here because of its historic importance as the first documented case of androgenic doping of a woman (for a detailed account, see ref. (11)). (a) 1968. The rectangle from July 28 to October 13 shows the period of drug administration, and the numbers above each date show the number of tablets taken per week (here, 14, or 10 mg per day). The curve presents the results of the specific competitions, showing the increase of strength and performance in a fully trained woman. At the time of the first drug application in 1968, the athlete had been well trained for almost 14 years. Under the influence of the drug, however, she gained unprecedented muscle strength and improved her records dramatically within a few weeks. (b) 1969. The steroid was given in three cycles and at various dosages, from 7 to 21 tablets per week (i.e., 5 15 mg daily). Without the drug, she could not reach 18 m but when taking the drug, she improved her world record once more, to 20.10 m. (c) 1972. She took even more of the androgenic hormone, with daily dosages of up to 7 tablets per day (35 mg), in four cycles, for a total androgenic load of 1450 mg for the year. This led to her top performances in the winter indoor season (left curve) as well as in the summer (right curve) and another personal best (20.22 m). Note the much lower performance at times off the drug or after only short periods of androgenization. Also, after 4 years of systematic androgenization, her basic strength level even when not taking the drug had also increased by ~1 m, indicative of a residual effect. (14)

Did all of this work for anyone else? Well, as I told you, virtually everyone who was involved with the East German Olympic Training program was on steroids of some kind, but OT was by and far away the most popular. They had access to some pretty weird stuff, too& intranasal testosterone, etc&

So... back to OT... it is notable from my readings on this compound that women saw much more positive effects from OT than men (this is true of all steroids, though). Women also saw more side effects, and generally found the side effects to be more severe and unbearable than their male counterparts. Unfortunately, they also (sometimes) tended to use higher dosages than the men did; often up to 2x as high. Lets take a look at their typical yearly doses:

Some documented dosages of androgenic-anabolic steroid (Oral-Turinabol)1 taken by female GDR medal winners (track and field) in Olympic Games, World Championships, and European Championships.2

(Annual dosage of OT in mgs followed by Events)
3680 Shot-put
3190 Discus
2900 Shot-put
2615 Shot-put
2590 Shot-put
1670 Sprint
1560 Hurdles
1480 Hurdles
1474 Sprint
1460 Sprint
1450 Shot-put
1405 Sprint
1380 Heptathlon
1375 Sprint
1340 Heptathlon
1255 Discus
1230 Heptathlon
1230 Hurdles
1185 Javelin

1. Additional injections of testosterone esters have not been considered here.

2. Data taken from ref. (14), which gives names and details. At least 12 of the drug-receiving competitors listed in this table set world records.

In keeping with Journal policy regarding confidentiality of patients and subjects, the names of subjects have been omitted.

Shocked? Don´t be. This was during the cold war, and victory in the Olympics was seen as a victory for a certain way of life and a certain ideology; defeat was unthinkable and unacceptable.

Is the recent reappearance of Oral-Turinabol on the black market going to change athletics or bodybuilding dramatically? No... I doubt it... a combination of price ($1/10mgs average) and availability may cause this stuff to remain an understated tool at our disposal. It is, however, a viable tool in a lean mass cycle, cutting cycle, or any athlete´s drug intake routine.

As a final reference, I´ll give you an example (direct from the East German State Doping Program´s reports) on how they used OT throughout the year, and with various other drugs (like Test Prop, for example):

(Anabolic and special preparation for the top competition of the year during the immediate preparation period in the Olympic cycle 1980/84, using the example of some selected long jumpers (W) and a high jumper (H) in combination with the results of competitions during this time)

Example (from hundreds of evaluations) showing typical administration patterns of orally taken synthetic anabolic-androgenic steroids (Oral-Turinabol, periods of application denoted by rectangles) and injections of testosterone esters [arrows, 10 mg of testosterone propionate (TP); triangles, 25 mg of TP; circles, 100 mg of testosterone enanthate plus 1500 IU of hCG], here given to high (H) and long (W, Weitsprung) jumpers during the last 10 weeks before a major international competition in 1981 1984 [immediate preparation period (UWV), in weeks, is indicated on the x-axis; WS, competition series preceding the UWV; the competition results (in meters) are shown immediately above the specific drug application symbols].(14)

Oral Turinabol Profile
(4-chlorodehydromethyltestosterone)
[4-chloro-17b-hydroxy-17a-methyl-androst-1,4-dien-3-one]
Molecular Weight:334.8854
Formula:C20H27O2Cl
Manufacturer: Underground Labs only
Effective Dose (Men): 10-40mgs/day
Effective Dose (Women): 5-15mgs/day
Active life: 16 hours
Detection Time: 6 weeks
Anabolic/ Androgenic ratio: >100:>0

References:

[The pharmacokinetics of Oral-Turinabol in humans] Pharmazie. 1991 Sep;46(9):650-4. German.
Department of Urology, Universitaetsklinikum "Carl Gustav Carus," Technical University of Dresden,Dresden, Germany
Influence of 1-double bond and 11 beta-hydroxy group on stereospecific microbial reductions of 4-en-3-oxo-steroids. J Steroid Biochem. 1986 Oct;25(4):561-6.
Intratesticular leiomyosarcoma in a young man after high dose doping with Oral-Turinabol: a case report. Cancer. 1999 Oct 15;86(8):1571-5.
GC and capillary column GC/MS determination of synthetic anabolic steroids. II. 4-chloro-methandienone (oral turinabol) and its metabolites. J Chromatogr Sci. 1983 Sep;21(9):405-10.
[Activation of the fibrinolytic system with dehydrochlormethyltestosterone] Folia Haematol Int Mag Klin Morphol Blutforsch. 1984;111(4):556-62. German.
[Modification of hypofibrinolytic states by dehydrochlormethyltestosterone] Folia Haematol Int Mag Klin Morphol Blutforsch. 1984;111(4):563-6. German.
[Application of microbial enzymes in studies of steroid metabolism (author´s transl)] Acta Microbiol Acad Sci Hung. 1975;22(4):397-402. Review. German.
[Application of microbial enzymes in studies of steroid metabolism (author´s transl)] Acta Microbiol Acad Sci Hung. 1975;22(4):397-402. Review. German.
[ON THE PHARMACOLOGY OF "ORAL TURINABOL".] Dtsch Gesundheitsw. 1965 Apr 15;20:690-1. German. No abstract available.
Berendonk B. Doping. Von der Forschung zum Betrug. Reinbek bei Hamburg: Rowohlt Taschenbuchverlag. 1992:448pp
[4-CHLORO-DELTA-1-METHYLTESTOSTERONE (ORAL TURINABOL), A NEW EFFECTIVE ORAL ANABOLIC STEROID.] Dtsch Gesundheitsw. 1965 Apr 15;20:670-4. German. No abstract available.
Bauersfeld K-H. Olek J. Meibner H. Hannemann D. Spenke J. Analyse des Einsatzes u. M. in den leichtathletischen Wurf/Stob-disziplinen und Versuch trainingsmethodischer Abteilungen und Verallgemeinerungen. Science Center of the DVfl 1973:41pp.
Clinical Chemistry 43:7. 1262-1279 (1997)

Stanozolol - winstrol

2007-08-10T22:56:00.000-07:00

Stanozolol - winstrol

Stanozolol, commonly sold under the name Winstrol (oral) and Winstrol Depot (intra-muscular), was developed by Winthrop Laboratories in 1962. It is a synthetic anabolic steroid derived from testosterone, and has been approved by the FDA for human use.
Unlike most injectable anabolic steroids, Stanozolol is not esterified and is sold as an aqueous suspension, or in oral tablet form. The drug has a large oral bioavailability, due to a C17 α-alkylation which allows the hormone to survive first pass liver metabolism when ingested. It is because of this that Stanozolol is also sold in tablet form.
Stanozolol has been used on both animal and human patients for a number of conditions. In humans, it has been demonstrated to be successful in treating anaemia and hereditary angioedema. Veterinarians may prescribe the drug to improve muscle growth, red blood cell production, increase bone density and stimulate the appetite of debilitated or weakened animals.
Stanozolol is one of the Anabolic steroids commonly used as an ergogenic aid and is banned from use in sports competition under the auspices of the International Association of Athletics Federations (IAAF).

Used illegally in bodybuilding, typically "stacked" with other testosterone-based anabolic steroids. Stanozolol is liked by many due to the fact it causes strength increases without excess weight-gain, promotes increases in vascularity, and will not convert to estrogen. It also does not cause excess water retention, and even sometimes is thought to have a diuretic effect on the body.
Stanozolol is commonly used by athletes and bodybuilders alike to lose fat while retaining lean body mass. It is usually used in a cutting cycle, to help preserve lean body mass while metabolizing adipose, although it has not been proven conclusively that it has any special fat-burning properties.
It is presented most commonly as a 50 mg/mL injection or a 50 mg tablet. However, recently 100 mg/mL versions have become available. A common dosage can be 25-100 mg/day, with optimal results usually seen at 50 mg/day. It is reduced to micrometer particles in aqueous suspension and does not have a typical elimination half-life. Authentic Stanozol can easily be seen, because it will separate in its container if left undisturbed for a number of hours (the micronized crystal will fall to the bottom, and the water suspension will rise to the top). It has a white, milky colour.
It should be taken no more than 48 hours apart, with some users preferring to inject every day, or even twice a day, to maintain serum levels.
The drug has been known to cause masculinising side-effects in women with doses as low as 2 mg per day, and liver damage has been known to occur with extended usage of larger doses.
An alternative to Stanzolol is Furazabol. Furazabol's effects are virtually identical to Stanzolol except that instead of having an extremely adverse effect on cholesterol values, Furazabol actually improves a person's blood lipid profile.[citation needed] Sold under the trade name Mitolan, Furazabol is a standard treatment in Japan for hyperlipemia.

Dianabol (methandrostenolone)

2007-08-09T22:43:00.001-07:00

Deca-Durabolin ( Nandrolone )

2007-08-08T09:38:00.000-07:00

Oxandrolone (Oxandrin) - ANAVAR

2007-08-07T09:18:00.001-07:00

Oxandrolone (Oxandrin) - ANAVAR

2007-08-06T10:24:00.001-07:00

Testosterone cypionate

2007-08-03T23:45:00.001-07:00

Testosterone cypionate

Quick overview:

Active Life: 15-16 days
Drug Class: Anabolic/Androgenic Steroid (for injection)
Average Dose: Men 250-1000 mg/week
Acne: Yes
Water Retention: Yes, high
High Blood Pressure: Yes
Liver Toxic: Low, except in mega dosages
Aromatization:Yes, high
DHT Conversion: Yes, high
Decrease HPTA function: Yes, severe

American athletes have a long and fond relationship with Testosterone cypionate. While Testosterone enanthate is manufactured widely throughout the world, cypionate seems to be almost exclusively an American item. It is therefore not surprising that American athletes particularly favor this testosterone ester. But many claim this is not just a matter of simple pride, often swearing cypionate to be a superior product, providing a bit more of a "kick" than enanthate. At the same time it is said to produce a slightly higher level of water retention, but not enough for it to be easily discerned. Of course when we look at the situation objectively, we see these two steroids are really interchangeable, and cypionate is not at all superior. Both are long acting oil-based injectables, which will keep testosterone levels sufficiently elevated for approximately two weeks. Enanthate may be slightly better in terms of testosterone release, as this ester is one carbon atom lighter than cypionate (remember the ester is calculated in the steroids total milligram weight). The difference is so insignificant however that no one can rightly claim it to be noticeable (we are maybe talking a few milligrams per shot). Regardless, cypionate came to be the most popular testosterone ester on the U.S. black market for a very long time

As with all anabolic steroids testosterone injectables, one can expect a considerable gain in muscle mass and strength during a cycle. Since testosterone readliy converts to estrogen, the mass gained from this drug is likely to be accompanied by quite a bit of water retention. The resulting loss of definition of course makes cypionate a very poor choice for dieting or cutting phases. The excess level of estrogen brought about by this drug can also cause one to develop gynecomastia rather quickly. Should one notice an uncomfortable soreness, swelling or lump under the nipple, an ancillary drug like Nolvadex should be added immediately. This will minimize the effect of estrogen greatly, making the steroid much more tolerable to use. The powerful anti-aromatases Arimidex, Femara, or Aromasin are yet a better choice. Those who have a known sensitivity to estrogen may find it more beneficial to use ancillary drugs like Nolvadex and Proviron from the onset of the cycle, in order to prevent estrogen related side effects before they become apparent.

Since testosterone is the primary male androgen, we should also expect to see pronounced androgenic side effects with this drug. Much intensity is related to the rate in which the body converts testosterone into dihydrotestosterone (DHT). This, as you know, is the devious metabolite responsible for the high prominence of androgenic side effects associated with testosterone use. This includes the development of oily skin, acne, body/facial hair growth and male pattern balding. Those worried that they may have a genetic predisposition toward male pattern baldness may wish to avoid testosterone altogether. Others opt to add the ancillary drug Proscar/Propecia, that prevents the conversion of testosterone to dihydrotestosterone. This can greatly reduce the chance for running into a hair loss problem, and will probably lower the intensity of other androgenic side effects. Although active in the body for much longer time, cypionate is injected on a weekly or bi-weekly basis in order to maintain stable blood levels. At a dosage of 250mg to 800mg per week we should certainly see dramatic results. It is interesting to note that while a large number of other steroidal compounds have been made available since testosterone injectables, they are still considered to be the dominant bulking agents among bodybuilders. There is little argument that these are among the most powerful mass drugs. When taking dosages above 800-1000mg per week there is little doubt that water retention will come to be the primary gain, far outweighing the new mass accumulation. The practice of "megadosing" is therefore inefficient, especially when we take into account the typical high cost of steroids today.

It is also important to remember that the use of an injectable testosterone will quickly suppress endogenous testosterone production. It is therefore mandatory to complete a proper post cycle therapy, constisting of HCG and Clomid or Nolvadex at the conclusion of a cycle. This should help the user avoid a strong "crash" due to hormonal imbalance, which can strip away much of the new muscle mass and strength. This is no doubt the reason why many athletes claim to be very disappointed with the final result of steroid use, as there is often only a slight permanent gain if anabolics are discontinued incorrectly. Of course we cannot expect to retain every pound of new bodyweight after a cycle. This is especially true whenever we are withdrawing a strong (aromatizing) androgen like testosterone, as a considerable drop in weight (and strength) is to be expected as retained water is excreted. This should not be of much concern; instead the user should focus on ancillary drug therapy so as to preserve the solid mass underneath. Another way athletes have found to lessen the "crash", is to first replace the testosterone with a milder anabolic like Deca-Durabolin. This steroid is administered alone, at a typical dosage (200-400mg per week), for the following month or two. In this "stepping down" procedure the user is attempting to turn the watery bulk of a strong testosterone into the more solid muscularity we see with nandrolone preparations. In many instances this practice proves to be very effective. Of course we must remember to still administer ancillary drugs at the conclusion, as endogenous testosterone production will not be rebounding during the Deca therapy.

Oral-Turinabol

2007-08-02T21:05:00.001-07:00

Deca-Durabolin ( Nandrolone )

2007-07-31T04:03:00.000-07:00

Oral-Turinabol

2007-07-30T03:11:00.001-07:00

Oral-Turinabol

2007-07-27T23:37:00.001-07:00

Anabolic and virilizing effects

2007-07-26T21:59:00.001-07:00

Oxandrolone (Oxandrin) - ANAVAR

2007-07-25T22:29:00.000-07:00

Testosterone cypionate

2007-07-25T01:38:00.001-07:00

Oxandrolone (Oxandrin) - ANAVAR

2007-07-23T20:49:00.000-07:00

Dianabol (methandrostenolone)

2007-07-22T22:35:00.001-07:00

Trenbolone

2007-07-21T03:50:00.001-07:00

Oxandrolone (Oxandrin) - ANAVAR

2007-07-06T11:51:00.001-07:00

Deca-Durabolin ( Nandrolone )

2007-07-04T22:09:00.001-07:00

Stanozolol - winstrol

2007-07-03T04:26:00.001-07:00

Stanozolol - winstrol

Human Growth Hormone (HGH)

2007-06-12T21:39:00.001-07:00

Human Growth Hormone (HGH)
(somatotropin)
Human growth hormone (Somatotropin) is produced in the body by the pituitary gland. Before this happens, Growth Hormone Releasing Hormone (HGHRH) and Somatostatin (SST) are released by the hypothalamus, and that determines whether more or less HGH is produced by the pituitary.(1) Many factors influence the release of HGH, however, including nutrition and exercise (6)(7).

Once it is released, Human Growth Hormone (HGH), which is also called Somatotropin (STH) has many functions in the human body. HGH is a protein that stimulates the body cells to increase both in size, as well as undergo more rapid cell division than usual. In addition, it enhances the movement of amino acids through cell membranes and also increases the rate at which these cells convert these molecules into proteins. Clearly, you can see that this would amount to an anabolic (muscle building) effect in the human body. HGH also has the ability to cause cells to decrease the normal rate at which they utilize carbohydrates, and simultaneously increase the rate at which they use fats.(1) Fat loss and lean mass increases with HGH have been found at a dose as low as . 0.028 iu/kg/daily for 24 weeks (4), however, in my estimation, that would be insufficient for a bodybuilder trying to gain muscle. Let´s use .028iu/kg as a working number; that´s 2.8iu for a 100kg (220lbs) bodybuilder. That´s certainly not unreasonable, and I would say that that dose to 2x that dose is the range most bodybuilders and athletes are finding their best results with. Also, that length of time used in the study I just mentioned (24 weeks) is very typical of HGH use, and in conversations with my friends who have used this compound, have told me that they experience consistent results starting well after the 2-month-mark, and they tend to either run this stuff for 6 months at a time, or year-round (if they have sufficient funds). One of my friends is able to consistently retain a shredded 6-7% body fat all year round with the assistance of HGH, whether he is on steroids or off. He also has noted that his cardio (fast walking, for an hour a day) was much easier while on HGH than when off, and certainly the research I´ve done would support his claim that sub maximal aerobic ability is improved with HGH use (5) (15).

How anabolic is this stuff? Well, even endurance athletes at rest (!) were observed in one study to be in an anabolic state (8). Yeah, so you can basically run marathons and take this stuff, and still build some muscle. Pretty impressive, right?

Growth Hormone is usually secreted in rhythmic pulses while you are sleeping, as two peptides, HGHRH and Somatostatin (SST) are alternately released. As you can guess, HGHRH (Growth Hormone Releasing Hormone) is the one responsible for the Release of Growth Hormone (And who said scientists have funny ways for naming things.(1)

Growth hormone also has the ability to stimulate the production (or reproduction, in the case of an injury) of cartilage. This, however, requires the presence of a mediator substance, Somatomedin (IGF), which is released from the liver in response to HGH, and the IGF, in turn, actually promotes the growth of cartilage.(1)

Although it requires IGF to actually grow new cartilage, HGH is directly able to stimulate the elongation of bone tissue.(1), and HGH has also been shown to elicit a positive effects on erythropoeisis (9), which is great for both anabolism as well as endurance.

Remember the negative feedback loop I always tell you about? Well, of course, your body has one which can stop the secretion of HGH, and it involves IGF. When your liver receives secretes IGF-1, it sends a message to both your Hypothalamus as well as your Pituitary to stop producing HGH. (1)

As you have probably guessed by now, your body produces the majority of it´s HGH during your early years, when you are experiencing growth spurts. As you get older, however, you just produce less of this stuff, and its effects are much less pronounced. This was the driving force behind the (always weird) life-extension crowd embracing HGH in the early 90´s. And, as usual, the driving force behind the athletic world embracing HGH was Dan Duchaine, which I´m sure comes as no surprise to many. He first wrote a teaser about it in his Underground Steroid Handbook, and then wrote extensively about it for the next couple of decades. At that time, Grorm, was being used. This nasty stuff was HGH extracted from (are you ready?): the pituitary of dead bodies? That´s real "Dawn of the Dead" style science, in my opinion. I guess it´s an advance from a couple of centuries ago, when Descartes (the "I think therefore I am" guy) declared the pituitary the part of the human body where the soul resides. Anyway, back to the cadaver-thing, the HGH extracted from the cadavers was found to be able to (in rare cases) carry a rare brain disease. This of course, infected the kids who received the infected HGH. The use of HGH from cadavers was subsequently discontinued. Back then (the 80´s) there was also a fake version of some purple looking HGH going around (it was HCG I believe, mixed with B-12) called "Rhesus Monkey Growth Hormone", which is pretty funny, looking back on it. To this day, however, if you get fake HGH, it´s still probably HCG, since both come presented as a powder and bacterioistatic water you need to use to reconstitute it (and then it needs to be refrigerated).

Even if you are using the non-cadaver-derived stuff (and at this point, I´m 100% sure that there´s none of the old Grorm left on shelves anywhere), it´s possible that you experience some side effects like carpal tunnel syndrome, acromegaly (a thickening or growth of bones, most noticeable in the feet, hands, and forehead), and enlarged organs. Gynocomastia is also possible as a side effect of HGH use, as well as Fluid retention (16) (the later being initially pointed out to me by a female colleague who had a pre-contest bodybuilder using HGH as part of his contest prep).

Now for some really interesting stuff:

Although HGH can easily produce very nice, high quality weight and muscle gains, it´s a very poor compound for inducing strength gains(2)(3)(4). That´s very counterintuitive, and certainly many strength athletes have experienced great results in strength as well as muscle size and fat loss from HGH. Generally, many studies have focused on HGH vs. HGH and exercise, and without the exercise LBM increases but not usually maximum voluntary strength output. It should also be noted that most athletes utilizing HGH are using it in a "cocktail" with (at least) anabolic steroids, and usually with IGF, thyroid meds, and other goodies such as an Aromatase Inhibitor.

Let´s discuss exactly why this is.

Most people who are taking the plunge into HGH use have reached a dead end with their use of anabolics, and need to push through that wall. I´m sure you´ve heard about the synergistic combination of using HGH along with Anabolic Steroids, IGF, insulin and T3 (* usually synthroid, a thyroid medication). The reason is that when these hormones are used correctly together, they´ll produce a large amount of synergy, the insulin is able to shuttle nutrients into your muscle, the thyroid hormone increases your fat-burning capability, the IGF will cause muscle growth as well as helping to grow new cartilage (thus preventing injury), and the anabolic steroids like testosterone, specifically (in addition to being anabolic) can increase IGF-1, in muscle tissue(11), and maybe even increase your body´s ability to use it. Also, usually, an increased amount of IGF usually tells your body to stop producing HGH, but testosterone actually blunts this part of the Negative FeedBack Loop (12)! And the addition of an Aromatase Inhibitor will also stop conversion of testosterone into estrogen; estrogen reduces IGF levels.(13)(14) Finally, the HGH does, well everything I just spent the last few pages telling you about!

Thus, IGF, Testosterone (and of course other steroids), Insulin, thyroid meds, and HGH will all combine to produce a pretty damned effective fat-burning and muscle building cycle! You know what else? HGH is virtually undetectable on any sort of currently used drug-screening tests. HGH, Insulin, Thyroid meds, and IGF may also be used pretty safely by those who may be subject to drug screening tests, or as a non-HPTA suppressive "bridge" between cycles.

Finally, I´ll tell you how I´d take HGH, personally. There was a study done on continuous HGH use vs. every other day injections (ED vs. EOD for the sake of brevity), with a equal total weekly dose. Although it´s counterintuitive, every other day injections produced better total growth in the kids in this (2 and 4 year long) study. Take a look at these graphs:

Growth velocity of children treated with alternate day HGH (the darker bars) or with a daily HGH regimen before, during, and 2 yr after stopping therapy. Values are the mean ± SD. *, P < 0.05; **, P < 0.01.(10)

Here´s another:

Pretreatment and cumulative 4-yr growth velocity of children treated with alternate day HGH ( the darker bars) or with a daily HGH regimen. Values are the mean ± SD. *, P < 0.00 (10)

Shooting HGH every other day more accurately replicates the pulsile frequency of HGH, and thus gave better results for growth (height) deficient children, HGH pulsatility is necessary for proper function of the HGH receptor.(10) Dosing in the EOD nature reduces incidence of any sort of withdrawal problems associated with normal HGH use, including regression or retardation of growth after cessation of therapy.

Therefore, I feel very comfortable speculating that the use of HGH in this manner, which more closely simulates the natural secretion pattern of it, allows the HGH receptors and the rest of the body to more efficiently recover from it, and this will result in much more muscle growth over time (although height was examined in the previous study). My recommendations therefore are 2 shots per day of .028iu/kg of bodyweight, taken every other day, for a minimum of 3months, and preferably for 2-3x that long, and preferably with the other synergistic compounds we´ve just taken a look at.

Buying HGH (Somatotropin)
You should be paying between $1.75-2.75 per IU of HGH, and since you are going to (necessarily) be buying it in bulk, you should be paying closer to the lower end of that.

Dianabol (methandrostenolone)

2007-06-02T10:18:00.000-07:00

Anadrol - Oxymetholone

2007-05-30T10:57:00.000-07:00

Stallone Convicted of Possession of Steroids

2007-05-25T09:37:00.000-07:00

Trenbolone

2007-05-22T11:50:00.001-07:00

Oral-Turinabol

2007-05-17T07:23:00.000-07:00

Stanozolol - winstrol

2007-05-13T11:51:00.000-07:00

Stanozolol - winstrol

Dianabol (methandrostenolone)

2007-05-12T00:45:00.001-07:00

Deca-Durabolin ( Nandrolone )

2007-05-06T12:29:00.001-07:00

Oxandrolone (Oxandrin) - ANAVAR

2007-05-04T15:55:00.000-07:00

Trenbolone

2007-04-30T09:32:00.000-07:00

Testosterone cypionate

2007-04-23T11:02:00.000-07:00

Testosterone cypionate

Quick overview:

Active Life: 15-16 days
Drug Class: Anabolic/Androgenic Steroid (for injection)
Average Dose: Men 250-1000 mg/week
Acne: Yes
Water Retention: Yes, high
High Blood Pressure: Yes
Liver Toxic: Low, except in mega dosages
Aromatization:Yes, high
DHT Conversion: Yes, high
Decrease HPTA function: Yes, severe

American athletes have a long and fond relationship with Testosterone cypionate. While Testosterone enanthate is manufactured widely throughout the world, cypionate seems to be almost exclusively an American item. It is therefore not surprising that American athletes particularly favor this testosterone ester. But many claim this is not just a matter of simple pride, often swearing cypionate to be a superior product, providing a bit more of a "kick" than enanthate. At the same time it is said to produce a slightly higher level of water retention, but not enough for it to be easily discerned. Of course when we look at the situation objectively, we see these two steroids are really interchangeable, and cypionate is not at all superior. Both are long acting oil-based injectables, which will keep testosterone levels sufficiently elevated for approximately two weeks. Enanthate may be slightly better in terms of testosterone release, as this ester is one carbon atom lighter than cypionate (remember the ester is calculated in the steroids total milligram weight). The difference is so insignificant however that no one can rightly claim it to be noticeable (we are maybe talking a few milligrams per shot). Regardless, cypionate came to be the most popular testosterone ester on the U.S. black market for a very long time

As with all anabolic steroids testosterone injectables, one can expect a considerable gain in muscle mass and strength during a cycle. Since testosterone readliy converts to estrogen, the mass gained from this drug is likely to be accompanied by quite a bit of water retention. The resulting loss of definition of course makes cypionate a very poor choice for dieting or cutting phases. The excess level of estrogen brought about by this drug can also cause one to develop gynecomastia rather quickly. Should one notice an uncomfortable soreness, swelling or lump under the nipple, an ancillary drug like Nolvadex should be added immediately. This will minimize the effect of estrogen greatly, making the steroid much more tolerable to use. The powerful anti-aromatases Arimidex, Femara, or Aromasin are yet a better choice. Those who have a known sensitivity to estrogen may find it more beneficial to use ancillary drugs like Nolvadex and Proviron from the onset of the cycle, in order to prevent estrogen related side effects before they become apparent.

Since testosterone is the primary male androgen, we should also expect to see pronounced androgenic side effects with this drug. Much intensity is related to the rate in which the body converts testosterone into dihydrotestosterone (DHT). This, as you know, is the devious metabolite responsible for the high prominence of androgenic side effects associated with testosterone use. This includes the development of oily skin, acne, body/facial hair growth and male pattern balding. Those worried that they may have a genetic predisposition toward male pattern baldness may wish to avoid testosterone altogether. Others opt to add the ancillary drug Proscar/Propecia, that prevents the conversion of testosterone to dihydrotestosterone. This can greatly reduce the chance for running into a hair loss problem, and will probably lower the intensity of other androgenic side effects. Although active in the body for much longer time, cypionate is injected on a weekly or bi-weekly basis in order to maintain stable blood levels. At a dosage of 250mg to 800mg per week we should certainly see dramatic results. It is interesting to note that while a large number of other steroidal compounds have been made available since testosterone injectables, they are still considered to be the dominant bulking agents among bodybuilders. There is little argument that these are among the most powerful mass drugs. When taking dosages above 800-1000mg per week there is little doubt that water retention will come to be the primary gain, far outweighing the new mass accumulation. The practice of "megadosing" is therefore inefficient, especially when we take into account the typical high cost of steroids today.

It is also important to remember that the use of an injectable testosterone will quickly suppress endogenous testosterone production. It is therefore mandatory to complete a proper post cycle therapy, constisting of HCG and Clomid or Nolvadex at the conclusion of a cycle. This should help the user avoid a strong "crash" due to hormonal imbalance, which can strip away much of the new muscle mass and strength. This is no doubt the reason why many athletes claim to be very disappointed with the final result of steroid use, as there is often only a slight permanent gain if anabolics are discontinued incorrectly. Of course we cannot expect to retain every pound of new bodyweight after a cycle. This is especially true whenever we are withdrawing a strong (aromatizing) androgen like testosterone, as a considerable drop in weight (and strength) is to be expected as retained water is excreted. This should not be of much concern; instead the user should focus on ancillary drug therapy so as to preserve the solid mass underneath. Another way athletes have found to lessen the "crash", is to first replace the testosterone with a milder anabolic like Deca-Durabolin. This steroid is administered alone, at a typical dosage (200-400mg per week), for the following month or two. In this "stepping down" procedure the user is attempting to turn the watery bulk of a strong testosterone into the more solid muscularity we see with nandrolone preparations. In many instances this practice proves to be very effective. Of course we must remember to still administer ancillary drugs at the conclusion, as endogenous testosterone production will not be rebounding during the Deca therapy.